National Library of Medicine Grants

Open National Library of Medicine grants

• AI Methods for Large Scale Epidemiological Studies using Patient Reports of Medication Adherence and Tolerability

  Up to $3.5MDeadline: Aug 31, 2029open

  Adherence to prescribed medications is a critical aspect of effective medical treatment, especially for chronic con- ditions; however, the World Healt...

• Supervised Weighted Distances: Patient Similarity to Explain Clinical AI Models

  Up to $2.7MDeadline: Aug 31, 2029open

  Summary Explaining complex, multivariate predictive models to clinicians and life scientists is difficult, but it is necessary to increase their trust...

• Data-driven discovery of host-microbiome protein-protein interactions

  Up to $1.8MDeadline: Aug 31, 2029open

  Research Summary Despite numerous large-scale metagenomic case-control studies that associate microbial taxa and genes with specific diseases, surpri...

• Computational methods for multiplex image analysis of the tumor microenvironment

  Up to $1.6MDeadline: Aug 31, 2029open

  Spatial biology techniques, such as multiplex immunofluorescence (mIF) imaging, enable detailed molecular profiling of tissue microenvironments while ...

• Statistical Methods for Integrating Irregularly Collected Longitudinal Multi-Modal data into Prediction Models

  Up to $1.5MDeadline: May 31, 2030open

  For individuals with chronic illnesses such as diabetes, heart failure, cancer, or obesity, early intervention prevents symptom escalation, acute care...

• Fast and slow prediction of stable and transient protein-protein interactions

  Up to $1.4MDeadline: Aug 31, 2029open

  Protein-protein interactions (PPIs) underpin processes ranging from transduction of signaling networks to maintenance of cellular structure. Identifyi...

• A computational framework for quality assessment and curation of models at scale

  Up to $1.4MDeadline: Aug 31, 2029open

  Model development is a common step of a research pipeline in many domains, including biology. However, most often there is no systematic approach to a...

• Preventing Medication Dispensing Errors in Pharmacy Practice with Risk-sensitive Artificial Intelligence

  Up to $1.4MDeadline: May 9, 2030open

  Preventable medication errors are a global problem that can cause significant patient harm and annually incur costs of $42 billion worldwide. In the U...

• Improving Safety and Trustworthiness in Data-Driven Decision Learning for Sepsis

  Up to $829KDeadline: Aug 31, 2027open

  The goal of this project is to develop robust machine learning approaches that improve the safety and trustworthiness of existing data-driven decision...

• Modernizing the Hierarchical Data Modeling Framework to Advance FAIR Data for Science

  Up to $582KDeadline: Aug 31, 2027open

  The goal of this project is to enhance the sustainability and impact of the Hierarchical Data Modeling Framework (HDMF), an open-source software tool ...

• Automating Viral Genome Annotation and Quality Control for Viruses of Public Health Importance

  Up to $530KDeadline: Aug 31, 2027open

  National Center of Biotechnology (NCBI) and International Nucleotide Sequence Database Collaboration (INSDC) databases have been cornerstones of publi...

• AL-MedLit: an active learning collaborative platform for biomedical literature classification and model evolution

  Up to $473KDeadline: Aug 31, 2028open

  The goal of this application is to support Lei Wang, Ph.D., as a Research Scientist and Research Software Specialist at The Ohio State University. He ...

• Novel Technologies for Detection and Monitoring of Lung Disease

  Up to $472KDeadline: Sep 15, 2026open

  / Abstract Obstructive lung diseases such as chronic obstructive pulmonary disease (COPD) and bronchial asthma affect approximately 42 million indivi...

• Accelerating Open Science through Enhanced Access to Catalogs of Metadata Templates

  Up to $462KDeadline: Aug 31, 2027open

  The proposed project aims to enhance Stanford’s CEDAR platform for creating and managing metadata in scientific research, ensuring that datasets are F...

• Enabling Large Scale Metabolomics Meta-Analyses and Data Integration of Metabolomics Workbench

  Up to $462KDeadline: Aug 31, 2027open

  (30 lines) The practical reuse of genomics and transcriptomics datasets is well-demonstrated due to the use of universal gene identifiers that facili...

• Enhanced Open-Source Zero-Footprint Web Viewer for Imaging Research

  Up to $447KDeadline: Aug 31, 2027open

  /Abstract The Open Health Imaging Foundation (OHIF) Viewer and its libraries, including Cornerstone3D, provide a professional-grade, open-source frame...

• Developing large language models for drug safety and effectiveness causal analysis

  Up to $403KDeadline: Jul 31, 2029open

  Because randomized controlled trials often severely underrepresent frail and complex patients, it is pivotal to inform physicians’ treatment choices w...

• HealthCoach: An LLM-driven chatbot to help patients gain actionable insights from their EHR notes and prepare for the next visit

  Up to $401KDeadline: Jun 30, 2029open

  When Steven Keating helped diagnose his own brain cancer from MRIs and health data in 2015, he became a resolute champion for patients’ access to thei...

• Virtual World-based Cardiac Rehabilitation to Promote Data-Powered Cardiovascular Health Among Cardiac Patients: A Multicenter Randomized Clinical Trial

  Up to $391KDeadline: Jul 31, 2029open

  Despite well-established benefits of reduced mortality and improved quality of life,

• The Last Mile of Interoperability: Integrating Outside Data Into Clinical Workflows to Improve Care

  Up to $376KDeadline: May 31, 2029open

  Building a nationally interoperable health care delivery system remains a top priority in US health care, with early studies theorizing that robust da...

Where National Library of Medicine grants go

Recent grant recipients are concentrated in these states. Funders sometimes fund outside their primary states for high-fit projects, so don't self-eliminate solely on geography — check each opportunity's stated eligibility.

How to apply for National Library of Medicine grants

Most National Library of Medicine applications require: an organizational profile with mission and programs, a project proposal aligned with the funder's stated priorities, a project budget, and supporting attachments (IRS determination letter, board list, recent financials). Federal applicants additionally need a SAM.gov UEI and an active Grants.gov account.