National Institute of Diabetes and Digestive and Kidney Diseases Grants

Open National Institute of Diabetes and Digestive and Kidney Diseases grants

• USDHub: community resource for Urinary Stone Disease research

  Up to $1.5MDeadline: May 31, 2029open

  Urinary stone disease (USD) is highly prevalent and contributes a substantial proportion of healthcare costs related to kidney and urologic disease. A...

• AIManage using an AI-driven CDS and chatbot for the management of patients on incretin mimetic medications

  Up to $847KDeadline: May 31, 2030open

  SUMMARY In the US, obesity affects 42% of the population and is associated with over $260 billion in direct medical costs annually. Highly efficacious...

• Identification and biological effects of microbiome-derived sulfated metabolites

  Up to $830KDeadline: Jun 30, 2030open

  /Abstract Recent studies have shown that metabolites produced by human gut bacteria causally influence health and disease. At the same time, the devel...

• Genetics of chronotype and impact on metabolic disease

  Up to $826KDeadline: Jun 30, 2030open

  / Abstract Dys-regulation of the body's internal circadian time-keeping mechanism is an established risk factor for metabolic disease. Chronotype, or ...

• Promoting healthy dietary intake among families with obesity via a grocery shopping intervention

  Up to $817KDeadline: Feb 28, 2031open

  Obesity is a diet-related disease that continues to be a major public health concern. Children who are overweight by age 5 are at increased risk for f...

• Precision administration of anti-thymocyte globulin with or without verapamil in adolescents and young adults with type 1 diabetes

  Up to $813KDeadline: Jun 30, 2030open

  /ABSTRACT Insulin is a replacement, not a curative, therapy in the management of type 1 diabetes (T1D) which is caused by loss of immune tolerance and...

• Targeting stress axes to enhance the efficacy of weight loss therapeutics

  Up to $802KDeadline: Feb 28, 2031open

  Obesity is a major problem in the U.S. and elsewhere. While pharmacotherapies, like glucagon-like peptide 1 receptor (GLP-1R) agonists, ease the burde...

• Initiation of anti-islet autoimmunity: Regulation of MHC class II expression in the islet microenvironment

  Up to $802KDeadline: Jun 30, 2029open

  Type 1 diabetes (T1 D), a prototypic CD4 T cell mediated autoimmune disease, is believed to have a prolonged pre-clinical phase that lasts many years....

• Tissue mechanics driving fibrosis in high cholesterol-associated steatotic liver disease

  Up to $790KDeadline: Feb 28, 2030open

  This project aims to develop theoretical models, validated through experiments, to explain the progression of Metabolic dysfunction-Associated Steatot...

• Virtual Housecalls: Redesigning Pediatric Primary Care Adolescent Obesity Treatment

  Up to $776KDeadline: Jul 31, 2030open

  Adolescents experience high prevalence of obesity and associated chronic diseases, such as type 2 diabetes mellitus, with persistent sociodemographic ...

• Delineating the impact of beige adipocytes in the metabolism

  Up to $772KDeadline: Apr 30, 2030open

  In this proposal, we address a critical gap in our understanding of adipose tissue biology and energy metabolism, with a focus on the role of beige ad...

• Programming of Monocyte and Macrophage Populations by Early-Life Glucocorticoid Exposure

  Up to $735KDeadline: Jun 30, 2030open

  Exposure such pituitary-adrenal (GC) been GC macrophages to adverse environments early in l ife is associate d with prevalent inflammatory human path...

• Fructose Metabolism Effects on the Liver: Unraveling the Role of Defective Intestinal GNG in Individuals with Obesity

  Up to $730KDeadline: Jun 30, 2030open

  The alarming rise in the rates of type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) persists despite efforts to address contributing facto...

• Chromatin remodeling factors and mechanisms in diabetic microvascular complications

  Up to $727KDeadline: Jun 30, 2030open

  Type 2 diabetes (T2D)-associated vascular dysfunction and inflammation drives the development of several debilitating microvascular complications (MVC...

• Neutrophil regulation of brown adipose tissue homeostasis

  Up to $710KDeadline: Jun 30, 2030open

  Brown adipose tissue (BAT) is a thermogenic fat pad that is essential for maintaining core body temperature and is associated with protection from num...

• The Role of O-GlcNAcylation in Corticotroph Physiology and Disease

  Up to $694KDeadline: Mar 31, 2030open

  /ABSTRACT Cushing’s disease (CD), caused by ACTH-secreting pituitary adenomas (ACTHomas), leads to debilitating metabolic, cardiovascular, and neurops...

• Sub-second catecholamine dynamics underlying food reward in humans

  Up to $684KDeadline: Dec 31, 2028open

  SUMMARY The prevalence of obesity in the United States (US) has been consistently rising. For individuals with obesity the lifetime risk of developing...

• Malassezia Immune Responses as Biomarkers of IBD

  Up to $681KDeadline: May 31, 2030open

  /ABSTRACT Inflammatory bowel disease (IBD) is the result of a dysregulated inflammatory immune response in the mucosa of the gastrointestinal tract. T...

• The Role of Mitochondria in Dysregulated Insulin Secretion in Obesity

  Up to $673KDeadline: Jul 31, 2030open

  Hyperinsulinemia precedes the development of Type 2 Diabetes (T2D) and is thought to play a key role in β-cell failure by increasing secretory workloa...

• Novel aspects of Gdf15 biology and function

  Up to $659KDeadline: Jan 31, 2029open

  Growth differentiation factor 15 (GDF15) is a stress-induced cytokine that is a biomarker of multiple disease states, including obesity and type 2 dia...

Where National Institute of Diabetes and Digestive and Kidney Diseases grants go

Recent grant recipients are concentrated in these states. Funders sometimes fund outside their primary states for high-fit projects, so don't self-eliminate solely on geography — check each opportunity's stated eligibility.

How to apply for National Institute of Diabetes and Digestive and Kidney Diseases grants

Most National Institute of Diabetes and Digestive and Kidney Diseases applications require: an organizational profile with mission and programs, a project proposal aligned with the funder's stated priorities, a project budget, and supporting attachments (IRS determination letter, board list, recent financials). Federal applicants additionally need a SAM.gov UEI and an active Grants.gov account.