National Institute of Neurological Disorders and Stroke Grants

Open National Institute of Neurological Disorders and Stroke grants

• Precision Editing of Granulin Mutations that Cause Frontotemporal Dementia

  Up to $6.6MDeadline: Jul 31, 2029open

  Frontotemporal dementia (FTD) is the most common form of presenile dementia before the age of 60, and no effective treatments are available. 40% of FT...

• Investigating aberrant vesicular degradation and lipid metabolism in neurodegeneration

  Up to $3.3MDeadline: Jul 31, 2029open

  BOSCO/MASSI – ABSTRACT Profilin-1 (PFN1) is an actin-binding protein that is best known for its role in regulating cytoskeletal dynamics. In 2012, we ...

• Neural Repair for Chronic Incomplete Cervical Spinal Cord Injury with Nogo Receptor Blockade plus Rehabilitative Training

  Up to $3.3MDeadline: Nov 30, 2030open

  SUMMARY Traumatic spinal cord injury (SCI) affects approximately 300,000 individuals in the United States, leading to persistent neurological deficits...

• Characterization of Antigen-Specific Immune Response in ALS

  Up to $3.2MDeadline: Jul 31, 2029open

  Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that primarily affects motor neurons (MNs) in the brain and spinal cord. The ...

• Spatial organization and conformational ensembles of amyloids inside cells

  Up to $3.2MDeadline: Jul 31, 2029open

  The formation of intracellular inclusions containing fibrillar aggregates of alpha-synuclein (α-syn) is a hallmark of neurodegenerative diseases such ...

• Anxiety and depression in a nonhuman primate model of synucleinopathy

  Up to $3.1MDeadline: Jul 31, 2029open

  Intraneuronal inclusions of aggregated Synuclein (Syn), termed Lewy bodies (LBs), are a pathological hallmark of Parkinson’s disease (PD), PD dementia...

• SARS-CoV-2 initiation and acceleration of AD pathology in the setting of endogenous and exogenous risk factors

  Up to $3.0MDeadline: Jul 31, 2029open

  The uncertain etiology of Alzheimer’s disease poses significant obstacles to the development of both therapeutic and prevention strategies. At the roo...

• The role of a metazoan-specific PQC system in protecting against TDP-43 proteinopathies

  Up to $2.8MDeadline: Jul 31, 2029open

  The overall goal of this application is to elucidate the role of TRIM10 in maintaining solubility and function of TDP-43 and protecting against TDP-43...

• The relationship between ocus-coeruleus-norepinephrine network and neurovascular coupling in health and disease

  Up to $2.8MDeadline: Jul 31, 2029open

  The brain requires a continuous supply of nutrients and oxygen to fuel its normal functioning.

• Structure-function relationships in alpha-synuclein strain biology

  Up to $2.7MDeadline: Jul 31, 2029open

  Cryo-electron microscopy (cryo-EM) studies have shown that protein fibrils isolated from patient samples adopt distinct misfolded conformations, which...

• Impact of SARS-CoV-2 on the cerebrovasculature as a risk factor for VCID: Role of Wnt/beta-catenin

  Up to $2.5MDeadline: Jul 31, 2029open

  COVID-19 increases the risk of vascular contributions to cognitive impairment and dementia (VCID). VCID is one of the most prevalent forms of dementia...

• Promoting Engagement and Clinical Trial Readiness for Alzheimer's Disease and Related Dementias Among Underserved Sexual and Gender Minorities

  Up to $2.2MDeadline: Jul 31, 2029open

  SUMMARY Sexual and gender minorities (SGM), defined here as individuals who identify as lesbian, gay, bisexual, transgender, queer, intersex, asexual,...

• Gene Therapy Consortium (GTC) for Gene-Based Clinical Trials Conducted within NeuroNEXT

  Up to $2.1MDeadline: Aug 14, 2026open

  The long-term objective of the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT) initiative is to efficiently translate advances in ne...

• Development of MMP-9 inhibitory monoclonal antibodies to relieve neuropathic pain

  Up to $2.1MDeadline: Jul 31, 2027open

  Diabetic neuropathic pain affects millions of Americans but there continues to be an unmet need for safe and effective pain medications. Opioids and n...

• BRAIN CONNECTS: Light microscopy for cell-type specific mesoscale to nanoscale dense connectomics

  Up to $2.0MDeadline: May 31, 2028open

  In recent years, there has been remarkable progress in mapping the connectivity of cell types in the brain. We now have complete connectomes for insec...

• Targeting Inflammation-Resolution Pathways to Limit VCID

  Up to $2.0MDeadline: May 31, 2029open

  There are currently no effective therapies to reduce vascular contributions to cognitive impairment and dementia (VCID), which contribute to the overa...

• In Vivo Characterization of White Matter Hyperintensity Using Individualized Analysis of Multimodal Imaging

  Up to $1.9MDeadline: Apr 30, 2029open

  White matter hyperintensities (WMHs) are common findings in older adults, appearing as high-signal areas on T2-weighted MRI scans. While often linked ...

• FDA Phase 1 Development of a Novel Nonopioid Cell and Tissue Permeable Peptide Therapeutic for Epigenetic Reprogramming of Neuropathic Pain

  Up to $1.5MDeadline: Jul 31, 2027open

  Neuropathic pain (NeP) affects an estimated 7-10% of the population. In the most severe cases, pain can be disabling, severely affecting a patient’s q...

• Neuronal Activity-Induced IEG Transcription Factors in Neurodevelopment and Plasticity

  Up to $1.2MDeadline: May 31, 2033open

  Neural circuits are continually shaped and reshaped during development and throughout life in response to ongoing experience. In addition to short-te...

• Development of Tissue Engineered Tregs as a Treatment for Acute Ischemic Stroke

  Up to $1.2MDeadline: Jul 31, 2027open

  In the U.S., nearly 800,000 individuals experience a stroke each year, predominantly ischemic strokes. The economic burden of stroke is staggering, wi...

Where National Institute of Neurological Disorders and Stroke grants go

Recent grant recipients are concentrated in these states. Funders sometimes fund outside their primary states for high-fit projects, so don't self-eliminate solely on geography — check each opportunity's stated eligibility.

How to apply for National Institute of Neurological Disorders and Stroke grants

Most National Institute of Neurological Disorders and Stroke applications require: an organizational profile with mission and programs, a project proposal aligned with the funder's stated priorities, a project budget, and supporting attachments (IRS determination letter, board list, recent financials). Federal applicants additionally need a SAM.gov UEI and an active Grants.gov account.