National Institute of Arthritis and Musculoskeletal and Skin Diseases Grants

Open National Institute of Arthritis and Musculoskeletal and Skin Diseases grants

• Leveraging inter-individual differences in walking pain and impairment to elucidate whole-person mechanisms of knee osteoarthritis

  Up to $4.9MDeadline: Aug 31, 2029open

  /Abstract Knee osteoarthritis (OA) is a common and debilitating condition, affecting millions in the United States of America. From 1990 to 2020, OA r...

• Investigating Mechanisms of Intra- and Inter-individual Pain Variability in Patients with Comorbid Chronic Pain and Depression

  Up to $2.9MDeadline: Apr 30, 2028open

  / ABSTRACT Chronic low back pain (cLBP) is the most common musculoskeletal pain condition associated with substantial inter-individual variability. Fu...

• Leveraging a National Pediatric Health Learning System for Phenotyping Pediatric Chronic Primary Pain to Advance Timely Patient-Centered Care

  Up to $2.3MDeadline: Jul 31, 2030open

  Chronic primary pain is common, impactful, and challenging to treat in children and adolescents. Unfortunately, many children do not get referred to, ...

• Elucidating the role of protein translation efficiency in T cell adaptation to human skin

  Up to $2.1MDeadline: May 31, 2030open

  Proposal Summary/Abstract T cell-mediated inflammatory and autoimmune skin diseases affect millions worldwide, with healthcare costs exceeding $100 bi...

• Uncovering Novel Microbial Factors That Enhance Wound Repair

  Up to $2.1MDeadline: Aug 31, 2028open

  Skin injuries and repair failures are a significant public health concern, with over 100 million new acute skin wounds occurring annually and non-heal...

• Engineered mRNA therapeutic for rotator cuff muscle repair

  Up to $2.1MDeadline: May 31, 2030open

  Rotator cuff (RC) tears are a leading cause of musculoskeletal impairment, affecting over 250,000 individuals annually in the United States. Despite s...

• Intra-articular corticosteroid injections for symptomatic osteoarthritis: The effects of injection dose, frequency, and timing on safety

  Up to $2.0MDeadline: Aug 31, 2028open

  / ABSTRACT Osteoarthritis (OA) is the most common type of arthritis and a frequent cause of pain and disability. Osteoarthritis annually affects ~595 ...

• Orchestrating Tendon Regeneration through Nanoparticle Drug Delivery

  Up to $2.0MDeadline: Aug 31, 2028open

  Tendon regeneration following acute injury is marred by a fibrotic healing response that impairs complete functional recovery. Despite the frequency o...

• Biopsychosocial determinants of pediatric-onset chronic musculoskeletal pain

  Up to $2.0MDeadline: Jul 31, 2030open

  Pediatric-onset chronic musculoskeletal pain disorders are common, but the mechanisms underlying their pathophysiology are poorly understood. Current ...

• Cellular Stress in Pain and Tissue Damage

  Up to $2.0MDeadline: Aug 31, 2028open

  Summary Osteoarthritis (OA) is influenced by factors like joint injury, age, and gender. Chronic pain is the primary debilitating symptom, and current...

• Post-transcriptional regulation of gene Expression during bone regeneration.

  Up to $1.9MDeadline: Aug 31, 2028open

  Co-transcriptional and post-transcriptional mechanisms play central roles in regulating gene expression. Understanding how these mechanisms control ge...

• Deranged Gut Homeostasis and the Pathogenesis of Fibromyalgia

  Up to $1.9MDeadline: Aug 31, 2028open

  Fibromyalgia (FM) is a chronic debilitating painful condition, affects millions of people in the U.S. alone, and is often refractory to the current tr...

• Investigating the plasticity of the follicular melanocyte stem cell system

  Up to $1.9MDeadline: Aug 31, 2028open

  Summary: This grant aims to understand the plasticity of melanocyte stem cells (McSCs) and mature melanocytes (Mcs) in adult hair follicles (HF). Our ...

• Dysregulation of epidermal innate immune signaling as driver of Psoriatic-like arthritis

  Up to $1.9MDeadline: Aug 31, 2028open

  Psoriasis affects 3% of the US population and a third of patients develop Psoriatic Arthritis (PsA), usually with a delay of 5-7 years. Delayed therap...

• Role of lysine acetylation in skeletal muscle contractile function

  Up to $1.9MDeadline: Aug 31, 2028open

  Skeletal muscle contractile function (i.e. its ability to generate force) underlies functional independence and is an important determinant of morbidi...

• Targeting Myofiber NAD(P)H Oxidases in Sepsis-Induced Myopathy

  Up to $1.8MDeadline: Aug 31, 2028open

  Sepsis is a life-threatening polymicrobial infection that affects approximately 49 million individuals worldwide each year and accounts for nearly 20%...

• Unraveling the Role of Langerhans Cells in Itch

  Up to $1.8MDeadline: Aug 31, 2028open

  Chronic itch is a considerable medical challenge associated with various skin and systemic diseases, , exerting a profound impact on patients' overall...

• Pathophysiology of Tubular Aggregate Myopathy

  Up to $1.7MDeadline: Aug 31, 2028open

  Tubular aggregate myopathy (TAM) is an inherited muscle disease associated with progressive weakness, cramps, myalgia, and exercise intolerance that p...

• Mitochondrial Oxidative Metabolism is a critical determinant of Muscle Satellite Cell fate & function

  Up to $1.6MDeadline: Aug 31, 2028open

  Muscle stem cells (MuSCs) give skeletal muscle the remarkable ability to completely regenerate following injury and play an important role in tissue m...

• Deconstructing the molecular and cellular mechanisms of psoriatic arthritis pain by an improved animal model

  Up to $1.6MDeadline: Aug 31, 2028open

  Modified Project Summary/Abstract Section Psoriasis (Ps) is an autoimmune-mediated systemic inflammatory skin disease. Approximately one-third of Ps p...

Where National Institute of Arthritis and Musculoskeletal and Skin Diseases grants go

Recent grant recipients are concentrated in these states. Funders sometimes fund outside their primary states for high-fit projects, so don't self-eliminate solely on geography — check each opportunity's stated eligibility.

How to apply for National Institute of Arthritis and Musculoskeletal and Skin Diseases grants

Most National Institute of Arthritis and Musculoskeletal and Skin Diseases applications require: an organizational profile with mission and programs, a project proposal aligned with the funder's stated priorities, a project budget, and supporting attachments (IRS determination letter, board list, recent financials). Federal applicants additionally need a SAM.gov UEI and an active Grants.gov account.