NIH Office of the Director Grants

Open NIH Office of the Director grants

• Modernization of a 600 MHz NMR Spectrometer with Solid-State Cryoprobe for Structural Analysis of Macromolecular and Cellular Assemblies

  Up to $1.8MDeadline: May 31, 2027open

  Support is requested for the acquisition of a solid-state CP-MAS CryoProbe and the associated upgrade for a shielded 600 MHz NMR magnet, to be housed ...

• Acquisition of a Bruker timsTOF Ultra 2 to Advance Clinical and Translational Proteomics at Children’s Hospital of Philadelphia

  Up to $1.2MDeadline: May 17, 2027open

  We request funds to acquire a Bruker timsTOF Ultra 2 mass spectrometers for the Proteomics Core Facility at the Children’s Hospital of Philadelphia (C...

• A 3D zebrafish microanatomical and gene expression atlas for disease modeling

  Up to $864KDeadline: Jul 31, 2029open

  The zebrafish is a vertebrate model organism with significant genetic, cellular, and physiological similarities with humans. Its powerful genetic and ...

• Optima Analytical Ultracentrifuge (AUC)

  Up to $671KDeadline: May 31, 2027open

  Funds are requested to purchase a Beckman-Coulter Optima Analytical Ultracentrifuge (AUC) equipped with Rayleigh interference, multi-wavelength UV-Vis...

• Cre-driver rat resource project R24

  Up to $655KDeadline: Jul 31, 2029open

  This R24 resource grant will leverage our existing infrastructure: personnel, expertise in rat transgenesis and gene editing, high throughput strain d...

• 400 MHz NMR Spectrometer

  Up to $450KDeadline: May 14, 2027open

  Project Description We request $450,305 to acquire a JEOL 400 MHz NMR spectrometer with a shielded magnet, 2-channel console, ROYAL HFX probe and auto...

• Molecular Mechanisms of Mutant IDH inhibition and DNA Damage in IDH-mutant Glioma

  Up to $413KDeadline: Jul 31, 2030open

  /Abstract: Gliomas are the most common primary brain tumors in adults, a subset of which have mutations in the metabolic gene isocitrate dehydrogenase...

• Examining the effects of naturalistic hallucinogen use on internalizing symptoms in a longitudinal sample of young adults

  Up to $413KDeadline: Jul 31, 2030open

  Hallucinogens are a heterogeneous group of substances that cause visual and auditory hallucinations, profound changes in one’s perception of time and ...

• Female Sexual Dysfunction and Distress in the Preconception and Perinatal Period

  Up to $409KDeadline: Jul 31, 2030open

  Female sexual dysfunction, defined as distressing impairments in sexual function, affects up to 40% of premenopausal women and represents a major publ...

• Decoding lineage-specific gene regulation across hematopoiesis

  Up to $406KDeadline: Jul 31, 2030open

  /ABSTRACT Sickle cell disease (SCD) and thalassemia are most common genetic disorders worldwide and cause early mortality and suffering. Reversal of t...

• Multicomponent hydrogels activating wound-induced hair neogenesis for scarless wound healing.

  Up to $406KDeadline: Jul 31, 2030open

  Proposal Summary/Abstract Candidate: Dr. Leo Wang holds a BA, MS, MD, and PhD from the University of Pennsylvania, where he completed dermatology resi...

• Decoding the beat: physiological control mechanisms for robust heart development

  Up to $406KDeadline: Jul 31, 2030open

  SUMMARY A robust heartbeat is essential for vertebrate life, as it is critical for sustained transport of nutrients and waste throughout large body pl...

• Chemoproteomics and Lipidomics for Identifying Dysregulated Enzymes and Lipids in Cutaneous Disorders.

  Up to $398KDeadline: Jul 31, 2030open

  This project aims to advance the treatment of atopic dermatitis (AD) by identifying novel drug targets through an innovative chemical biology platform...

• Understanding the Impact of Clonal Hematopoiesis on Aging Human Bone Marrow

  Up to $389KDeadline: Jul 31, 2030open

  /ABSTRACT Every year there are two million new cases of cancer diagnosed in the United States and 600,000 cancer-related deaths. Preventing the develo...

• Building precision disease-responsive gene therapy

  Up to $385KDeadline: Jul 31, 2030open

  Achieving precise spatiotemporal control of gene expression is critical to maximize the delivery of in vivo gene therapy. Adenoviral-associated viruse...

• Deciphering the principles and mechanism of RNA structure

  Up to $385KDeadline: Jul 31, 2030open

  /Abstract: This project seeks to address the significant challenges in RNA structure, an area that remains underdeveloped despite RNA’s critical roles...

• Novel high-throughput approaches to discover and dissect human transcriptional protein interactions

  Up to $350KDeadline: Jul 31, 2030open

  /ABSTRACT Understanding transcription factors in human cells is essential for insights into development, health, and disease. However, our understandi...

• Illuminating the spatial and temporal diversity of the gastrointestinal microbial ecosystem with label-free nonlinear optical microscopy

  Up to $281KDeadline: Jul 31, 2030open

  /ABSTRACT Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal condition that affects an estimated 2.4-3.1 million people in the US. IBD is...

• Modernization of Sterilization Equipment to Support Research at Emory National Primate Research Center

  Up to $277KDeadline: Aug 14, 2027open

  To meet the current and projected future research demand (over $94 million in research grants in FY24), the Emory National Primate Research Center (EP...

• Acquiring a mass photometer for Clemson University

  Up to $235KDeadline: May 31, 2027open

  /ABSTRACT Clemson University’s rapid growth in externally funded research has propelled it to R1 status, reflecting its expanding impact in advanced ...

Where NIH Office of the Director grants go

Recent grant recipients are concentrated in these states. Funders sometimes fund outside their primary states for high-fit projects, so don't self-eliminate solely on geography — check each opportunity's stated eligibility.

How to apply for NIH Office of the Director grants

Most NIH Office of the Director applications require: an organizational profile with mission and programs, a project proposal aligned with the funder's stated priorities, a project budget, and supporting attachments (IRS determination letter, board list, recent financials). Federal applicants additionally need a SAM.gov UEI and an active Grants.gov account.