National Human Genome Research Institute Grants

Open National Human Genome Research Institute grants

• Scalable software engineering and methods for large-scale subcellular spatial omics

  Up to $3.4MDeadline: Aug 31, 2029open

  / Abstract Emerging spatial subcellular transcriptomics technologies represent a major advancement in biological research, offering to study the relat...

• Advancing rare disease discovery through technological and methodological approaches using an intuitive platform, seqr

  Up to $3.3MDeadline: Jun 30, 2029open

  / ABSTRACT Over half of all rare disease families remain undiagnosed following exome and genome sequencing analysis. Remarkable developments in genomi...

• Computational and Statistical Methods for Genetic Association Studies of Disease Course Over Time

  Up to $3.3MDeadline: Aug 31, 2029open

  ABSTRACT Genome-wide association studies (GWAS) have been remarkably successful at mapping genomic loci for complex human diseases. However, most stu...

• SERVICE: Newborn genomic sequencing and federally-supported early intervention

  Up to $3.3MDeadline: Jun 30, 2029open

  Newborn whole genome sequencing (N-WGS), applied to healthy or critically-ill newborns, can identify rare genetic conditions which may have establishe...

• PRISM: Ethically-guided multimodal AI models for predicting disease pathogenesis in individuals with pathogenic variants

  Up to $3.2MDeadline: Aug 31, 2027open

  This project aims to develop machine learning and artificial intelligence tools to enhance prediction of disease manifestation in individuals with pat...

• Patient centered prediction of clinically important outcomes arising from pathogenic variants

  Up to $3.2MDeadline: Jul 31, 2027open

  / ABSTRACT As genetic testing becomes more common in medical care, an increasing number of individuals will discover that they carry a pathogenic vari...

• Beginning genetic interventions in infants (BEGIN)

  Up to $3.2MDeadline: Mar 31, 2030open

  The advancements in genomic medicine have significantly accelerated over the past decade. However, their translation into clinical practice have been ...

• Southeastern Genomic Medicine eConsult Network (SeGMeNt)

  Up to $3.0MDeadline: Mar 31, 2028open

  Advances in our understanding of the role of genetic variation in human diseases and the technologies for genomic analysis and therapy have the potent...

• SouthEast GEnomic Medicine eConsult Service (SE-GEMS)

  Up to $2.9MDeadline: Feb 29, 2028open

  Integrating genomic medicine into routine healthcare holds immense promise for improving patient outcomes through more timely testing, diagnosis, and ...

• Enhancing Access to Genomic Expertise: A Comprehensive Implementation Strategy for the Western Regional Genomic eConsult Network (WestGEN)

  Up to $2.8MDeadline: Feb 29, 2028open

  /Abstract The rapid advancement of genomic medicine holds great promise for improving diagnosis, treatment, and health outcomes across diverse populat...

• High-throughput interrogation of long-range enhancers

  Up to $2.8MDeadline: Aug 31, 2029open

  /Abstract A majority of heritable disease-causing variation resides in the non-coding portions of the genome. The leading hypothesis is that these var...

• Niche Trajectory Analysis of Spatial Omics Data

  Up to $2.6MDeadline: Mar 31, 2030open

  The maintenance and function of a tissue/organ depends on cell-cell interactions among different cell types. The cell-cell interactome responds and re...

• Experimental-data-based in-silico data generation platform to improve the accuracy and reliability of single-cell and spatial omics data analysis

  Up to $2.4MDeadline: Aug 31, 2029open

  This project aims to develop a suite of advanced yet practical statistical tools with user-friendly interfaces to enhance the reliability and power of...

• Democratizing Genomic Data Science: Exploring the Impact of Cloud-Based Platforms on Data Access and Use

  Up to $2.3MDeadline: Mar 31, 2030open

  Identifying and promoting biomedical research practices, including responsible data stewardship and analysis, that advance broad public health benefit...

• Computational methods for phasing biobank sequence data

  Up to $2.3MDeadline: Aug 31, 2029open

  Next-generaƟon biobanks will contain sequence data for millions of individuals. This project will develop genotype phasing methods for these immense d...

• Sequence-to-function models for mechanistic investigations of personal genomes

  Up to $2.2MDeadline: Aug 31, 2029open

  Recent advances in functional genomics and computational modeling and hardware have ushered in a new era of sequence-to-function (S2F) deep learning m...

• Population Genomics Screening Network (PGSN) Coordinating Center

  Up to $2.1MDeadline: Feb 29, 2028open

  Translating knowledge of the genetic basis of disease into better health outcomes is the major promise of translational genomic medicine and precision...

• Baylor College of Medicine - Mendelian Genomics Research Center (BCM-MGRC)

  Up to $2.1MDeadline: Apr 30, 2027open

  The Baylor College of Medicine node of the NHGRI GREGoR program (BCM-GREGoR) has built on the extensive discoveries and infrastructure established in ...

• Pediatric Mendelian Genomics Research Center

  Up to $1.9MDeadline: Mar 31, 2027open

  The supplement instructions PA-26-001 state: “At a minimum, the Research Strategy or Program Plan section, as applicable, must be completed and must i...

• Partnership To Support Indigenous-driven Genomic Research

  Up to $1.6MDeadline: Jun 30, 2027open

  Southcentral Foundation’s (SCF) proposed Building Partnerships and Broadening Perspectives to Advance Ethical, Legal, and Social Implications (BBAER) ...

Where National Human Genome Research Institute grants go

Recent grant recipients are concentrated in these states. Funders sometimes fund outside their primary states for high-fit projects, so don't self-eliminate solely on geography — check each opportunity's stated eligibility.

How to apply for National Human Genome Research Institute grants

Most National Human Genome Research Institute applications require: an organizational profile with mission and programs, a project proposal aligned with the funder's stated priorities, a project budget, and supporting attachments (IRS determination letter, board list, recent financials). Federal applicants additionally need a SAM.gov UEI and an active Grants.gov account.