National Heart Lung and Blood Institute Grants

Open National Heart Lung and Blood Institute grants

• Impact of Asymptomatic CMV on Cardiovascular Event Risk in Treated HIV

  Up to $3.0MDeadline: Jul 31, 2029open

  People with HIV (PWH) remain at higher risk for Type 1 myocardial infarction (T1MI), ischemic stroke, and venous thromboembolism (VTE) than the genera...

• Optimizing HCT Outcomes: A Multi-omic Investigation

  Up to $2.0MDeadline: May 31, 2030open

  Hematopoietic stem cell transplantation (HCT) is an essential treatment for high-risk non-malignant and malignant hematologic diseases. However, outco...

• A Novel ENaC Blocker/Osmolyte Inhalation Solution for the Treatment of Muco-Obstructive Lung Diseases

  Up to $2.0MDeadline: Jul 31, 2027open

  Muco-obstructive lung diseases, e.g., COPD, asthma, CF, and PCD, cause major health problems to many citizens of the US. Recent CT data have identifie...

• Optimized development of novel leaflet biomaterials for replacement heart valves

  Up to $1.4MDeadline: May 31, 2029open

  The ideal replacement heart valve (RHV) should have sufficient durability, resistance to thrombosis, and excellent hemodynamics that lasts the remaini...

• iPRISM (Imaging-enhanced Prediction of RIsk for Sudden cardiac death in hcM)

  Up to $1.3MDeadline: May 31, 2029open

  Hypertrophic cardiomyopathy (HCM) is an inherited heart condition where the heart is thicker than normal. It is an inheritable genetic condition and t...

• Molecular and Translational Studies in Hematologic Disorders

  Up to $1.3MDeadline: Feb 28, 2032open

  This application for an NHLBI R35 Outstanding Investigator Award is to continue R35-funded studies on mech- anism of disease in von Willebrand Disease...

• Precision Circadian Medicine for Shift Workers in the Digital Era

  Up to $1.1MDeadline: Mar 31, 2033open

  /Abstract All essential 24-hr operations (e.g., first responders, hospital services) rely on nightshift workers who forgo nocturnal sleep for work. Th...

• Estrogen signaling in chronic asthma

  Up to $1.0MDeadline: Jul 31, 2027open

  Epidemiological data show increased incidence and severity of asthma in women, which likely reflects both inherent sex differences and importantly the...

• Development of a Totally Implanted Left Ventricular Assist Device

  Up to $1.0MDeadline: Feb 29, 2028open

  /Abstract In the United States (US) ~6.5 million people have heart failure (HF), there are ~1 million new cases each year, and ~250,000 patients die o...

• 2/2 A Phase 2 Study of Elafin (Tiprelestat) for the Treatment of Pulmonary Arterial Hypertension (PAH)

  Up to $937KDeadline: Jul 31, 2030open

  The ATHENA trial represents a new paradigm to slowing the progression of disease in people with pulmonary arterial hypertension (PAH). With our clinic...

• Aerosolized Chemically Modified Tetracycline Nanoformulation for the Treatment of Acute Respiratory Distress Syndrome

  Up to $887KDeadline: Feb 28, 2028open

  /ABSTRACT CMTx Biotech is a drug development company working to rescue, develop and commercialize a proprietary clinical-stage drug candidate, incycli...

• Application of Modern Methods to Predict Risk and Estimate Treatment Effectiveness in Cardiogenic Shock

  Up to $817KDeadline: May 31, 2029open

  /ABSTRACT Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) is a major driver of global morbidity and mortality. Due to the chall...

• Optimizing Medications and Lung Health in People with HIV through Pharmacist-led Proactive E-Consults (OPTIMIZE Lung-HIV)

  Up to $804KDeadline: May 31, 2030open

  /ABSTRACT Despite effective antiretroviral therapy (ART) for people with HIV (PWH), community acquired pneumonia remains a common cause of hospitaliza...

• RBC-bound cell-free DNA as a predictor of acute anemia in sickle cell disease

  Up to $798KDeadline: Feb 28, 2031open

  /Abstract Sickle cell disease (SCD) is characterized by a chronic, relatively stable anemia that is punctuated by acute drops in hemoglobin. These acu...

• Incorporating Donor Lung CT Images into Machine Learning Models to Predict Severe Primary Graft Dysfunction after Lung Transplantation

  Up to $782KDeadline: May 31, 2029open

  /ABSTRACT Primary graft dysfunction (PGD) is a form of acute lung injury that occurs in the first 72 hours after lung transplantation. PGD is the lead...

• Unraveling The Mechanism of Heart Failure in Hypertrophic Cardiomyopathy with Exercise CMR

  Up to $777KDeadline: Jan 31, 2030open

  Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, with heart failure (HF) being the most common adverse complication and cau...

• Endothelial protocadherins in vascular development and disease

  Up to $776KDeadline: May 31, 2029open

  Transcription factors Klf2 and 4 are strongly induced in vascular endothelial cells (ECs) by fluid shear stress from blood flow, where they confer vas...

• Continuous Positive Airway Pressure, Arousability and Links to Mechanisms in Obstructive Sleep Apnea (CALM-OSA).

  Up to $765KDeadline: May 31, 2030open

  New approaches to understanding the mechanisms of treatments for obstructive sleep apnea (OSA) are desperately needed. OSA affects fifty-four million ...

• Medial Arterial Calcification in Peripheral Artery Disease

  Up to $761KDeadline: Dec 31, 2028open

  Peripheral artery disease (PAD) is highly prevalent in older adults and is a comorbidity to diseases such as diabetes, chronic kidney disease, and hyp...

• Hydrogen Sulfide and GLP-1 Combination Therapy to Treat HFpEF

  Up to $759KDeadline: May 31, 2029open

  Heart failure (HF) is a leading cause of cardiovascular morbidity and mortality, imposing a significant healthcare burden on 6.7 million Americans tha...

Where National Heart Lung and Blood Institute grants go

Recent grant recipients are concentrated in these states. Funders sometimes fund outside their primary states for high-fit projects, so don't self-eliminate solely on geography — check each opportunity's stated eligibility.

How to apply for National Heart Lung and Blood Institute grants

Most National Heart Lung and Blood Institute applications require: an organizational profile with mission and programs, a project proposal aligned with the funder's stated priorities, a project budget, and supporting attachments (IRS determination letter, board list, recent financials). Federal applicants additionally need a SAM.gov UEI and an active Grants.gov account.