National Institute of General Medical Sciences Grants

Open National Institute of General Medical Sciences grants

• Decoding Positional Epigenetic Memory

  Up to $3.1MDeadline: Jul 31, 2029open

  / ABSTRACT: DECODING POSITIONAL EPIGENETIC MEMORY Hox gene expression is crucial for patterning the main body axis of all bilaterian species. In a cla...

• Understanding the Metabolic Regulation of Immune Responses to Bacterial Infections

  Up to $2.2MDeadline: Jul 31, 2029open

  /Abstract: My research program investigates how the host metabolism impacts immune responses during infection. While immune evasion strategies by bact...

• Deciphering the cellular origins and impact of toxic formaldehyde in mammalian cells

  Up to $2.1MDeadline: Jul 31, 2029open

  Formaldehyde is a well-recognized human genotoxin found commonly in the environment but also produced endogenously in mammalian cells. While environme...

• Single molecule dissection of Arp2/3 complex activity and regulators in living cells

  Up to $2.0MDeadline: Jul 31, 2029open

  Actin assembly by the Arp2/3 complex is an essential component of a large and expanding list of cellular processes that are necessary for life. Theref...

• High Throughput End-to-End Design of Quantitative Phase Microscopy based on Customizable Nano-Optics

  Up to $2.0MDeadline: Jul 31, 2029open

  Imaging cytometry provides biomedically important morphological features of cells or tissues via high- speed acquisition hardware and fast image proce...

• Regulation of the mitotic DNA damage response

  Up to $1.9MDeadline: Jul 31, 2029open

  /ABSTRACT Overview: DNA double-strand breaks (DSBs) that are present during mitosis can lead to severe genome instability. While cells have robust DNA...

• DNA Protein Cross-Links: Metabolic Sources and Repair

  Up to $1.8MDeadline: Jul 31, 2029open

  DNA-protein cross-links (DPCs) form when cellular proteins become irreversibly trapped to DNA as a result of cellular processes such as histone demeth...

• National Center for Translational and Developmental Proteomics

  Up to $1.8MDeadline: Jul 31, 2030open

  Despite the central role for proteins as primary mediators of cell phenotype and function, proteomics has lagged genomics and transcriptomics as a too...

• Cellular and Molecular Biology Training Program

  Up to $1.6MDeadline: Jun 30, 2030open

  The Cellular and Molecular Biology (CMB) Training Program has contributed to the success of over 1,700 graduate student trainees for nearly 50 years. ...

• pan-XLSM: an AI-powered microscopy platform for imaging and analysis of highly expanded tissue samples

  Up to $1.4MDeadline: Jun 30, 2027open

  Addressing the complexities of biological function and disorders at the molecular level requires a spatial biology technology that can map the 3D dist...

• Identifying and modulating mechanistic cellular paths of quiescence deepening and transition to senescence

  Up to $1.4MDeadline: May 31, 2030open

  Quiescence and senescence are two distinct cellular dormancy states that play critical roles in tissue homeostasis, regeneration, and aging. Despite a...

• Pseudouridine detection with single-base resolution in a multiplexed epitranscriptomics assay

  Up to $1.1MDeadline: Jul 31, 2027open

  Chemical modifications to the canonical nucleosides are found throughout human RNA and collectively constitute the epitranscriptome. They are critical...

• Medical Scientist Training at UMCMS

  Up to $1.0MDeadline: Jun 30, 2030open

  /ABSTRACT Our MD-PhD Program was founded in 1983 and first obtained NIH MSTP funding in 2013. We currently have a steady enrollment of about 80 studen...

• Mechanisms of Mpro autocleavage

  Up to $584KDeadline: May 31, 2029open

  SARS-CoV-2, the virus that causes COVID-19, relies on a critical enzyme called Mpro (main protease) to reproduce inside infected cells. This enzyme mu...

• Molecular Basis for Transmembrane Conduction & Signaling

  Up to $576KDeadline: Jul 31, 2030open

  /ABSTRACT This proposal seeks to determine fundamental mechanisms of action of integral membrane proteins at the level of atomic structure, and energy...

• Next-Generation Native Ion Mobility-Mass Spectrometry Methods for the Characterization of Biotherapeutics

  Up to $566KDeadline: Feb 28, 2031open

  Biopharmaceuticals, including therapies based on proteins and nucleic acids, are now among the most important classes of modern medicines. While they ...

• Drivers of adaptation and colonization within individual human microbiomes

  Up to $558KDeadline: Apr 30, 2030open

  LOCAL AND GLOBAL SELECTIVE FORCE WITHIN MICROBIOMES The human microbiome harbors a large capacity for within-person adaptive mutations. Commensal bact...

• Imaging Single Photocatalytic Turnovers in Photoredox Catalysis for Efficient DrugSynthesis

  Up to $554KDeadline: May 31, 2029open

  Photoredox catalysis has been widely used in organic synthesis over the past decade. It has attracted significant attention from the pharmaceutical in...

• Empowering Genomics Educators: Scalable and Effective Training Models to Build a Skilled Biomedical Workforce through Course-based Undergraduate Research Experiences

  Up to $542KDeadline: Jun 30, 2030open

  The Genomics Education Partnership (GEP) is a nationwide consortium of 265 faculty at 213 institutions from 39 states, D.C., and Puerto Rico. Annually...

• A Mentoring and Skills Development Training Program in One Health

  Up to $536KDeadline: Apr 30, 2030open

  The goal of the Mentoring and Skills Development Training Program in One Environmental Health Toxicology (MSDT-OEHT) dovetails with NIGMS R25 IPERT ob...

Where National Institute of General Medical Sciences grants go

Recent grant recipients are concentrated in these states. Funders sometimes fund outside their primary states for high-fit projects, so don't self-eliminate solely on geography — check each opportunity's stated eligibility.

How to apply for National Institute of General Medical Sciences grants

Most National Institute of General Medical Sciences applications require: an organizational profile with mission and programs, a project proposal aligned with the funder's stated priorities, a project budget, and supporting attachments (IRS determination letter, board list, recent financials). Federal applicants additionally need a SAM.gov UEI and an active Grants.gov account.