Department of Energy (DOE) Office of Science Grants

Open Department of Energy (DOE) Office of Science grants

• Energy Frontier Research Centers (EFRC) Program

  Deadline: Jul 1, 2026open

  Energy Frontier Research Centers (EFRC) Program is sponsored by Department of Energy (DOE) Office of Science. This funding opportunity accelerates bre...

  clean_energyquantum_computingmaterials_scienceenergy frontiercritical minerals

• Building EPSCoR-State/National Laboratory Partnerships

  Deadline: Jul 1, 2026open

  Building EPSCoR-State/National Laboratory Partnerships is a grant from Department of Energy (DOE) Office of Science that these partnerships advance un...

  basic_researchconvergence_researchhigher_educationepscornational laboratories

• The Genesis Mission: Transforming Science and Energy with AI

  Deadline: Dec 17, 2026open

  The Genesis Mission: Transforming Science and Energy with AI is a grant from Department of Energy (DOE) Office of Science that in addition, this RFA w...

  artificial_intelligenceai_scienceclean_energyenergy_efficiencydata_science

• Quantum Information Science Research Centers

  open

  Quantum Information Science Research Centers is a grant from Department of Energy (DOE) Office of Science that funds The Office of Science issues two ...

  quantum_computingbasic_researchai_sciencequantum information sciencequantum computing

• Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs (DOE)

  open

  Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs (DOE) is a grant from the Department of Energy (DOE) ...

  small_businessinnovationsmall business innovationtechnology transferresearch and development

• DOE Office of Science Funding Opportunities

  open

  DOE Office of Science Funding Opportunities represent a broad portfolio of competitive research grants and cooperative agreements issued annually by t...

  basic_researchbiomedical_researchenvironmental_educationclimate_changebiological sciences

• FY 2026 Continuation of Solicitation for the Office of Science Financial Assistance Program

  open

  FY 2026 Continuation of Solicitation for the Office of Science Financial Assistance Program is sponsored by Department of Energy (DOE) Office of Scien...

  basic_researchenergy_efficiencybiomedical_researchclimate_changeclean_energy

• DOE Office of Science Open Cross‑Cutting Funding Opportunity Announcements

  open

  DOE Office of Science Open Cross‑Cutting Funding Opportunity Announcements is sponsored by Department of Energy (DOE) Office of Science. Open, year‑ro...

  small_business

• AI and Machine Learning Research (Office of Science)

  open

  AI and Machine Learning Research (Office of Science) is sponsored by Department of Energy (DOE) Office of Science. This grant funds scientific machine...

  artificial_intelligenceai_foundation_modelsai_scienceenergy_efficiencybasic_research

• Artificial Intelligence and Machine Learning Research

  open

  Artificial Intelligence and Machine Learning Research is sponsored by Department of Energy (DOE) Office of Science. Supports research in AI and machin...

  artificial_intelligenceai_foundation_modelsai_climateenergy_efficiencyai_science

• Small Business Technology Transfer (STTR) Program

  open

  Small Business Technology Transfer (STTR) Program is sponsored by Department of Energy (DOE) Office of Science. The DOE STTR program focuses on techno...

  small_businessai_social_goodenergy_efficiencydata_sciencetechnology transfer

• AI and Machine Learning Research (DOE Office of Science)

  open

  AI and Machine Learning Research (DOE Office of Science) is sponsored by Department of Energy (DOE) Office of Science. This grant funds scientific mac...

  artificial_intelligenceai_foundation_modelsai_scienceenergy_efficiencymachine learning

• Opportunities through the Nanoscale Science Research Centers (NSRCs)

  open

  Opportunities through the Nanoscale Science Research Centers (NSRCs) is sponsored by Department of Energy (DOE) Office of Science. The Nanoscale Scien...

  materials_sciencebasic_researchbiotechnologynanoscale sciencenanotechnology research

• SBIR/STTR FY 2024 Phase I Release 2

  open

  SBIR/STTR FY 2024 Phase I Release 2 is sponsored by Department of Energy (DOE) Office of Science. The DOE SBIR/STTR programs encourage U. S.

  small_businessclean_energyenergy_efficiencyinnovationsbir

• AI and Machine Learning Research (Scientific Discovery through Advanced Computing - SciDAC)

  open

  AI and Machine Learning Research (Scientific Discovery through Advanced Computing - SciDAC) is sponsored by Department of Energy (DOE) Office of Scien...

  artificial_intelligenceai_foundation_modelsai_scienceenergy_efficiencymachine learning

• AI for Science Funding Opportunities

  open

  AI for Science Funding Opportunities is sponsored by Department of Energy (DOE) Office of Science. The Genesis Mission: Transforming Science and Energ...

  artificial_intelligenceai_foundation_modelsai_sciencedata_sciencebasic_research

• Small Business Innovation Research (SBIR) Program

  open

  The Small Business Innovation Research (SBIR) Program from the Department of Energy (DOE) Office of Science funds small businesses conducting R&D with...

  clean_energycybersecuritydefense_researchsmall business innovation researchsbir

How to apply for Department of Energy (DOE) Office of Science grants

Most Department of Energy (DOE) Office of Science applications require: an organizational profile with mission and programs, a project proposal aligned with the funder's stated priorities, a project budget, and supporting attachments (IRS determination letter, board list, recent financials). Federal applicants additionally need a SAM.gov UEI and an active Grants.gov account.