South Dakota Grants

Top South Dakota grants right now

• ExpandQISE: Track 2: Quantum Materials Institute: 2D Materials, heterostructures and metasurfaces for compact, efficient entangled photon-pair generation for quantum communications

  Up to $5.0MDeadline: Sep 30, 2029open

  This Expanding Capacity in Quantum Information Science and Engineering (ExpandQISE) project establishes a Quantum Materials Institute at the South Dak...

• NRT: Training Scientists to Solve Biofilm Challenges Using Artificial Intelligence and Smart Materials

  Up to $3.0MDeadline: Aug 31, 2030open

  This National Science Foundation Research Traineeship (NRT) award to the South Dakota School of Mines and Technology, in collaboration with the Univer...

• ICE-TI: Maka Kin Awayankapi (Stewards of Earth)

  Up to $2.3MDeadline: May 31, 2030open

  A goal of the Tribal Colleges and Universities Program (TCUP) is to increase the science, technology, engineering and mathematics (STEM) instructional...

• Collaborative Research: FEC: Establishing Infrastructure for AI-Driven Discovery of Small Molecules to Combat Antibiotic Resistance, Biofilms, and Aflatoxin Contamination

  Up to $2.2MDeadline: Jul 31, 2029open

  This project will develop methods to discover and design small molecules that control harmful microbes, prevent microbial-induced infrastructure deter...

• EPSCoR Graduate Fellowship Program (EGFP): Enhancing Development of Innovative Materials for Agriculture, Human Health, and Quantum Science

  Up to $1.9MDeadline: Jun 30, 2028open

  The National Science Foundation (NSF) EPSCoR Graduate Fellowship Program (EGFP) supports EGFP designated institutions and programs in EPSCoR jurisdict...

• Equipment: MRI: Track 1 Acquisition of a Scanning Transmission Electron Microscope for Materials Research at the South Dakota School of Mines and Technology

  Up to $1.4MDeadline: Jul 31, 2027open

  The project involves acquisition of a modern field emission scanning transmission electron microscope (FE-STEM) in support of nanoscale investigations...

• Beginnings: Dakota Biotechnology Rural Workforce Development Program

  Up to $998KDeadline: Sep 30, 2028open

  The Dakota Biotechnology Rural Workforce Development Program is responsive to a regional workforce need by enabling current STEM students and recent S...

• CAREER: Discovery of Composition-Enriched Cosmic Ray Anisotropy with the IceCube Neutrino Observatory

  Up to $900KDeadline: Jun 30, 2030open

  Cosmic rays, which are mostly made up of atomic nuclei, carry energies that far exceed what we can achieve with our human-made accelerators. Despite t...

• Dual Effects of Endocannabinoid Modulation in Nociception

  Up to $750KDeadline: Jun 30, 2027open

  Pain is a complex physiological and behavioral process that is still poorly understood. One example of our lack of understanding how pain works is the...

• Collaborative Research: E-RISE RII: BioNitrogen Economy Research Center

  Up to $747KDeadline: Jul 31, 2028open

  The BioNitrogen Economy Research Center (BNERC) will build state-wide research capacity focused on biological nitrogen fixation and its practical appl...

• Equipment: MRI: Track 1 Acquisition of Microbioreactor for Advancing Biological, Environmental, and Biomanufacturing Research

  Up to $687KDeadline: Aug 31, 2028open

  An award is being made to South Dakota School of Mines and Technology to enable the acquisition of the BioLector XTM microbioreactor system. This syst...

• Elucidating spatiotemporal dynamics of nascent extracellular matrix in response to platinum treatment in ovarian cancer

  Up to $584KDeadline: Apr 30, 2030open

  High-grade serous ovarian carcinoma (HGSC) is the most common type of ovarian cancer and has the 3rd highest mortality-to-incidence ratio of all cance...

• NSFGEO-NERC: Carbon concentration and variability in Earth’s mantle

  Up to $537KDeadline: Feb 28, 2029open

  What controls carbon concentration and variability in the Earth’s mantle is an important unanswered question. This project will address this question ...

• CAREER: Evaluating models of intracratonic structural reactivation: A case study of the Black Hills, western South Dakota

  Up to $520KDeadline: May 31, 2030open

  Earth’s continents have grown progressively throughout geologic time by aggregation of crustal blocks along major fault zones. As a result, continenta...

• Probing the mechanisms of dependency underlying skeletal genetic pathways of p53 and Notch in the pathogenesis of osteosarcoma

  Up to $490KDeadline: Mar 31, 2030open

  The goal of this proposal is to understand cancer dependency pathways that regulate premalignant osteoblasts and the development of osteosarcoma. Oste...

• Aptamers as Novel Inhibitors of the Neurotoxin Beta-methylamino-L-alanine (BMAA)

  National Institute of Environmental Health SciencesUp to $484KDeadline: Jul 31, 2028open

  Exposure to specific environmental factors are believed to play a role in the development of many neural pathologies. Early studies linked chronic exp...

• Neurotrophic Drug Development for Alzheimer's Disease

  Up to $475KDeadline: Mar 22, 2027open

  Drug development for the cognitive deficits in Alzheimer’s Disease has proven to be challenging. Although major progress has been made in understandin...

• REU Site: Black Hills Applied Ceramic Engineering

  Up to $457KDeadline: Aug 31, 2027open

  Ceramics are used in many industries and various applications that range from thermal insulators for spacecraft to more practical applications like br...

• Regulation of Nucleocytoplasmic Compartmentalization

  Up to $457KDeadline: Jan 31, 2031open

  /ABSTRACT The nuclear envelope is a specialized extension of the endoplasmic reticulum that surrounds the eukaryotic cell nucleus, effectively compart...

• BRC-BIO: Mechanistic regulation of dynamic gene expression patterns by temporal JNK activation

  Up to $453KDeadline: Apr 30, 2028open

  A fundamental feature of life is the ability to process information to initiate an appropriate response. This research project seeks to understand how...

Where South Dakota grants come from

• Federal sources — Grants.gov, NIH RePORTER, and SAM.gov, filtered for opportunities that fund work in South Dakota.
• South Dakota state portal — state-administered grant programs, including pass-through federal dollars and state-only appropriations.
• Foundations — community foundations and private foundations active in South Dakota, drawn from IRS Form 990 filings and curated foundation directories.
• Corporate giving — a curated set of corporate philanthropy programs that explicitly fund South Dakota-based work.

Listings are refreshed daily and stale data is flagged. Local funders missing from your area? You can request ZIP-level coverage after creating a free account.

Qualify South Dakota grants before you write

Most of the time it takes to win a grant isn't writing — it's research and qualifying. Before you commit a week to a full proposal, qualify the opportunity with a 1–2 page Letter of Inquiry. Our guide walks through the structure that gets a yes: