South Carolina Grants

Open funding for nonprofits, schools, and municipalities serving South Carolina.

100 open South Carolina grants, drawn from federal sources, the state portal, foundation 990 filings, and corporate giving programs. Refreshed daily.

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Top South Carolina grants right now

  • NSF and Computer Science Teachers Association AI Professional Development Weeks Computer Science Foundations for Creating with AI

    U.S. National Science Foundation (NSF) awarded to Computer Science Teachers Association (CSTA)Up to $11Mopen

    Artificial Intelligence Professional Development Weeks: CS Foundations for Creating with AI is an $11 million two-year NSF initiative awarded to the C...

    ai_educationai_literacyk12_ai_teacher_pdcomputer_science_educationai_curriculum
  • StrokeNet Thrombectomy Endovascular Platform (STEP)

    Up to $8.4MDeadline: Feb 28, 2027open

    Stroke is the fourth leading cause of disability within the United States. Large vessel occlusion (LVO) subtype of acute ischemic stroke (AIS) is the ...

  • NIAID SPF MACAQUE BREEDING COLONIES

    Up to $8.4MDeadline: Sep 29, 2026open

    The Nonhuman Primate Transplantation Tolerance Cooperative Study Group (NHPCSG) was established to advance transplantation research through use of non...

  • Exploring Strategies to Strengthen Student Transfer to Engineering

    Up to $5.0MDeadline: Sep 30, 2031open

    This project will contribute to the national need for well-educated scientists, mathematicians, engineers, and technicians by supporting the retention...

  • The South Carolina Clinical & Translational Research Institute (SCTR)

    National Center for Advancing Translational SciencesUp to $3.8MDeadline: Mar 31, 2032open

    Since 2009, the South Carolina Clinical and Translational Research Institute (SCTR) has transformed the research environment across South Carolina (SC...

  • Eco-evolutionary dynamics of Escherichia coli in an island system: Environmental drivers of waterborne urinary tract infections

    John E. Fogarty International Center for Advanced Study in the Health SciencesUp to $3.0MDeadline: Aug 31, 2030open

    Urinary tract infections (UTIs) affect over 400 million people annually and are a leading driver of antibiotic use worldwide, contributing to the grow...

  • Advanced Fibrosis Detection and a Predictive Diagnostic Model for Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in Primary Care

    Up to $2.7MDeadline: Aug 31, 2029open

    Advanced Fibrosis Detection and a Predictive Diagnostic Model for Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in Primary Care. Me...

  • BIO-AI: RESEARCH-PGR: Harnessing Multi-Omics and AI/ML to Unveil Nutrient Recycling Mechanisms in Maize Senescence

    Up to $2.4MDeadline: Aug 31, 2029open

    In plants, like corn, leaf aging (also known as senescence) is accompanied by regular cellular and physiological changes. Some of these changes are ou...

  • Life’s end Benefits of CannaBidiol and TetrahYdrocannabinol (LiBBY) Open-Label Extension (OLE) Study

    National Institute on AgingUp to $2.1MDeadline: Jul 31, 2028open

    /ABSTRACT This project will be conducted in the context of the Alzheimer’s Clinical Trials Consortium (ACTC), which is a consulting group of over 100 ...

  • Research Administration Capacity Heightening in South Carolina (REACH-SC)

    Up to $2.0MDeadline: Aug 31, 2026open

    Societal shifts in work, along with the aging of the higher education workforce, are exacerbating already existing challenges in the research enterpri...

  • Building Scientific Self-Identity and Sense of Belonging in Preparing Academically Talented, Low-Income Students for Successful STEM Careers

    Up to $2.0MDeadline: Jan 31, 2030open

    This project will contribute to the critical national demand for well-educated scientists, mathematicians, engineers, and technicians by supporting th...

  • Transdisciplinary Approach to Strengthening Students’ Identity, Persistence to Degree, and Career Success in STEM

    Up to $2.0MDeadline: Apr 30, 2031open

    This project will contribute to the national need for well-educated scientists, mathematicians, engineers, and technicians by supporting the retention...

  • RESP-FIT: A Respiratory Muscle Strength Training Intervention for COPD

    Up to $2.0MDeadline: Feb 28, 2030open

    Chronic obstructive pulmonary disease (COPD) is a leading cause of death in the U.S. (3rd worldwide) and disproportionately affects individuals living...

  • Building Leadership among Science Teachers in Rural Regions: Designing, Developing, and Implementing a Science Teacher Leadership Academy

    Up to $1.9MDeadline: Jul 31, 2029open

    This Noyce Track 3 project aims to serve the national need to extend the knowledge base around effective strategies for teacher and teacher leader ret...

  • Collaborative Research: Engaging K-8 Teachers in Integrating Computer Science, AI, and Cybersecurity into Standard-Based Teaching

    Up to $1.9MDeadline: Aug 31, 2029open

    As artificial intelligence (AI) becomes increasingly embedded in the technologies used by both students and teachers, it is essential for them to unde...

  • Impact of 12-month Postpartum Insurance Extensions on Maternal and Newborn Health

    Up to $1.7MDeadline: Aug 31, 2027open

    The United States is experiencing a maternal health crisis. Maternal mortality and severe maternal morbidity (SMM) affect around 700 and 60,000 women,...

  • Robert Noyce Teacher Scholarship Program Track 3 Project: Building High-Quality Computer Science Teacher Leaders

    Up to $1.6MDeadline: Sep 30, 2030open

    This Noyce Track 3 project aims to serve the national need of developing highly effective computer science teachers. Additionally, this project aims t...

  • RII Track 2 FEC: Enabling Factory to Factory (F2F) Networking for Future Manufacturing

    Up to $1.6MDeadline: Sep 30, 2026open

    Cyber infrastructure and artificial intelligence (AI) are core components of smart manufacturing in South Carolina (SC), West Virginia (WV), and the U...

  • NSF-BSF: The Study of Nuclear Physics with Intermediate Energy Probes

    Up to $1.5MDeadline: Aug 31, 2027open

    Although ninety-eight percent of the mass of ordinary matter is due to the strong subatomic force, many features of this force remain a puzzle. This a...

  • Equipment: MRI: Track 1 Acquisition of a Mobile Observation System for Neurodevelopment Research

    Up to $1.4MDeadline: Aug 31, 2027open

    With Major Research Instrumentation support, Dr. Jessica Bradshaw and collaborators acquire a mobile, integrated, behavior-brain-physiology capture sy...

Where South Carolina grants come from

  • Federal sources — Grants.gov, NIH RePORTER, and SAM.gov, filtered for opportunities that fund work in South Carolina.
  • South Carolina state portal — state-administered grant programs, including pass-through federal dollars and state-only appropriations.
  • Foundations — community foundations and private foundations active in South Carolina, drawn from IRS Form 990 filings and curated foundation directories.
  • Corporate giving — a curated set of corporate philanthropy programs that explicitly fund South Carolina-based work.

Listings are refreshed daily and stale data is flagged. Local funders missing from your area? You can request ZIP-level coverage after creating a free account.

Qualify South Carolina grants before you write

Most of the time it takes to win a grant isn't writing — it's research and qualifying. Before you commit a week to a full proposal, qualify the opportunity with a 1–2 page Letter of Inquiry. Our guide walks through the structure that gets a yes:

Read: How to write a Letter of Inquiry that gets you invited to apply

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