Substance Use & Recovery Grants

Top opportunities

• Broad Agency Announcement for Extramural Biomedical and Human Performance Research and Development (HT9425-23-S-SOC1)

  U.S. Army Medical Research Acquisition Activity (USAMRAA)Up to $50MDeadline: May 27, 2026open

  Broad Agency Announcement for Extramural Biomedical and Human Performance Research and Development (HT9425-23-S-SOC1) is sponsored by U.S. Army Medica...

  biomedical_researchhealth_disparitiesmental_healthsubstance_abusepublic_health

• Tobacco Grant Program FY 2026/27

  California Department of Justice (Office of the Attorney General)Up to $29MDeadline: Jun 19, 2026open

  Tobacco Grant Program FY 2026/27 is sponsored by California Department of Justice (Office of the Attorney General). This program supports local law en...

  public_healthsubstance_abusehealth_disparitiescommunity_developmenttobacco control

• Cohort Studies of HIV/AIDS and Substance Use in Miami

  Up to $7.4MDeadline: Jun 30, 2030open

  This is a proposal for the continuation of the well-characterized Miami Adult Studies on HIV (MASH) cohort of middle-to-old, aged people living with a...

• BJA FY25 Comprehensive Opioid, Stimulant, and Substance Use Program (COSSUP) Investigations Training and Technical Assistance (TTA)

  Bureau of Justice AssistanceUp to $3.0MDeadline: May 13, 2026open

  This NOFO will support specialized training and technical assistance (TTA) to Comprehensive Opioid, Stimulant, and Substance Use Program (COSSUP) gran...

• Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

  Up to $3.0MDeadline: Aug 21, 2028open

  Max award: $3,000,000 Eligibility: Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Comm...

• Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

  National Institutes of HealthUp to $3.0MDeadline: Aug 21, 2028open

  The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions ...

• CASCADE: A North Carolina cohort to address the cascading effects of the HIV and substance use syndemic

  Up to $2.5MDeadline: Jul 31, 2030open

  The US Deep South bears the highest burden of HIV, and the South is lagging behind in achieving Ending the HIV Epidemic (EHE) goals. People who use dr...

• A binational cohort of the intersection between substance use, HIV, and associated comorbidities among people who inject drugs in San Diego, CA

  Up to $2.4MDeadline: May 31, 2030open

  We will prospectively study the intersection between substance use, HIV and related co-morbidities in a cohort of people who use drugs (PWUD) in San D...

• Enhancing Access to Timely Research to Prevent HIV Transmission and Effectively Treat Substance Use

  Up to $2.4MDeadline: Jun 30, 2029open

  The purpose of this proposed Avenir Award is to achieve widespread population health improvements in preventing HIV transmission and overdose amongst ...

• Transforming systems of care to address HIV, HIV risk, and substance use disorders in prisons

  Up to $2.3MDeadline: May 31, 2029open

  To End the HIV Epidemic in the US, we must transform care quality and access in prisons. People who are incarcerated in state prisons face a dispropor...

• Neighborhood conditions, neural circuits, and substance use behaviors across the early life course.

  Up to $2.3MDeadline: Jun 30, 2029open

  The etiology of substance use disorders (SUD, i.e., alcohol, cannabis, cocaine, opioids) are multifactorial, with risk factors including adverse socia...

• Stimulant and Polysubstance use, Inflammation and Sex Effects on Myocardial Disease in HIV (SPISE)

  Up to $2.3MDeadline: Mar 31, 2030open

  /ABSTRACT Heart failure (HF) and other cardiovascular diseases (CVDs) constitute a leading cause of death in people with HIV (PWH). Compared to people...

• Characterizing genetic effects on molecular phenotypes at the single-cell resolution across brain regions in the context of substance use disorder and HIV

  Up to $2.3MDeadline: Feb 28, 2030open

  Millions of individuals are affected with substance use disorders (SUD), posing a significant burden on these individuals, their families, and communi...

• Responding to the Increase in Substance Use, HIV, HCV, and Overdose in New England (RISE-NE)

  Up to $2.1MDeadline: May 31, 2030open

  Background: Despite the availability of robust substance use prevention and treatment services in some communities, sizable HIV outbreaks are occurrin...

• Using Multimodal Data Science To Gain Actionable Insights For Substance Misuse Prevention

  Up to $1.8MDeadline: Aug 31, 2026open

  Substance misuse, encompassing opioid misuse, non-opioid illicit use, and alcohol misuse, constitutes a heterogeneous set of conditions associated wit...

• High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)

  National Institutes of HealthUp to $1.5MDeadline: Mar 5, 2027open

  The purpose of this Funding Opportunity Announcement (FOA) is to support high priority research at the intersection of HIV and substance use. This FOA...

• High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)

  Up to $1.5MDeadline: Mar 5, 2027open

  Max award: $1,500,000 Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian Ame...

• “GLP-1 Outcomes with people Using Psychoactive Substances (GLOW-UPS): a multi-stage, multi-site trial among persons involved in the criminal-legal system

  Up to $1.4MDeadline: May 31, 2030open

  This proposal is a large hybrid type 1 implementation effectiveness randomized controlled trial evaluating the comparative effectiveness of long-actin...

• Mitochondrial oxidative phosphorylation in substance use disorder and HIV

  Up to $1.4MDeadline: Dec 31, 2030open

  This proposal aims to address the intertwined epidemics of HIV-associated neurocognitive disorders (HAND) and opioid use disorder (OUD) in the context...

• Shifting the Landscape in Primary Substance Use Prevention for Rural America: The Integrated Community Engagement (ICE) Collaborative Cluster Trial

  Up to $1.2MDeadline: Jul 31, 2030open

  Summary Abstract Rural vs urban adolescents have higher rates of substance use, driven by social, economic, and geographic risk factors. Adolescent us...

What's included in substance use & recovery grants

We track grants tagged with the following keywords. If your work uses different language internally, AI mission-fit search (available after signup) will catch the conceptual matches that exact-keyword filtering misses.

How GrantMind sources these grants

• Federal sources — Grants.gov, NIH RePORTER, and SAM.gov, filtered for opportunities tagged or thematically aligned with substance use & recovery.
• State portals — state-administered programs across all 50 states and D.C.
• Foundations — community and private foundations active in this category, drawn from IRS Form 990 filings and curated foundation directories.
• Corporate giving — a curated set of corporate philanthropy programs.

Make these grants count

The leverage point isn't writing more proposals — it's qualifying funders before you write. A 1–2 page Letter of Inquiry tells you in days whether a foundation is going to fund you, instead of forty hours from now. Our guide walks through the structure that gets a yes: